Finasteride and dutasteride may reduce melanoma risk
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منابع مشابه
Finasteride and dutasteride may reduce melanoma risk.
Malignant melanoma is an androgen-dependent tumor. Androgen blockade enhances response to the melanoma vaccine. In their study, Zhang et al reported that a history of teenage acne in women may be a novel risk factor for melanoma independent of other risk factors. Acne in women is related to androgens and can be treated with finasteride. Both finasteride and dutasteride prevent the conversion of...
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BACKGROUND The prostate cancer prevention trial (PCPT) and Reduction by dutasteride of Prostate Cancer Events (REDUCE) trial found that 5α-reductase (5αR) inhibitors finasteride and dutasteride respectively, decreased prostate cancer prevalence but also increased the incidence of high-grade tumors. 5αR2 is the main isoenzyme in normal prostate tissue; however, most prostate tumors have high 5αR...
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Use of aromatase inhibitors, which are known to reduce endogenous oestrogen levels, as adjuvant therapy had a lower risk of endometrial cancer, compared with that of patients who were treated with tamoxifen, results of a new study show. In this study, Rowan Chleblowski and colleagues (Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA) examined the rec...
متن کاملThe Different Reduction Rate of Prostate-Specific Antigen in Dutasteride and Finasteride
PURPOSE To compare and analyze the therapeutic effects and changes in the prostate-specific antigen (PSA) level with treatment with finasteride or dutasteride for benign prostatic hyperplasia (BPH) for 1 year. MATERIALS AND METHODS We retrospectively investigated patients who suffered from BPH for 1 year between January 2005 and December 2008. For treatment groups, we divided the patients int...
متن کاملPersistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride
IMPORTANCE Case reports describe persistent erectile dysfunction (PED) associated with exposure to 5α-reductase inhibitors (5α-RIs). Clinical trial reports and the manufacturers' full prescribing information (FPI) for finasteride and dutasteride state that risk of sexual adverse effects is not increased by longer duration of 5α-RI exposure and that sexual adverse effects of 5α-RIs resolve in me...
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ژورنال
عنوان ژورنال: Cancer
سال: 2015
ISSN: 0008-543X
DOI: 10.1002/cncr.29520